Addition of uridines to edited RNAs in trypanosome mitochondria occurs independently of transcription.

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Structured PICO

Population

Trypanosoma brucei mitochondria (isolated organelle system)

Intervention

Post-transcriptional addition of nucleotides (CTP, ATP, UTP) in the absence of transcription

Outcome

Incorporation of uridines into edited RNAssurrogate

Demonstrates that RNA editing in trypanosome mitochondria is a post-transcriptional process independent of transcription.

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RNA editing proceeds post-transcriptionally in trypanosomes; leaves open relevance to human mitochondrial transcripts or cardiovascular models.

Harris et al. (1990) studied this question.

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RNA editing proceeds post-transcriptionally in trypanosomes; leaves open relevance to human mitochondrial transcripts or cardiovascular models.