Key result
A higher high-sensitivity C-reactive protein to albumin ratio was associated with an increased risk of MACCE (HR per SD increase 1.07; 95% CI 1.01-1.14; P=0.024) in CHD patients undergoing PCI.
Why the study?
Limited studies have examined the impact of high-sensitivity C-reactive protein to albumin ratio on cardiovascular outcomes in patients undergoing PCI.
Does a higher high-sensitivity C-reactive protein/albumin ratio predict MACCE and MI in CHD patients undergoing PCI with DES?
Cohort (n=9,375)
Does a higher high-sensitivity C-reactive protein/albumin ratio predict MACCE and MI in CHD patients undergoing PCI with DES?
Hazard Ratio: 1.07 (95% CI 1.01–1.14)
Absolute Event Rate: 12.3% vs 8.7%
p-value: p=.024
The high-sensitivity C-reactive protein to albumin ratio serves as an independent predictor of MACCE and MI in patients with coronary heart disease undergoing DES implantation.
Limited studies have focused on the impact of high-sensitivity C-reactive protein (hsCRP) to albumin ratio (CAR) on cardiovascular outcomes in patients undergoing percutaneous coronary intervention (PCI). Hence, the present study evaluates the association between CAR and cardiovascular outcomes in patients undergoing drug-eluting stent (DES) implantation. We consecutively enrolled 9375 CHD patients undergoing DES implantation. All patients were divided into 3 groups according to their CAR: tertile 1 (CAR ≤.02, n=3125), tertile 2 (.02 .06, n = 3125). The primary endpoint was major adverse cardiovascular and cerebrovascular events (MACCE). Kaplan-Meier analysis indicated that the incidences of MACCE and MI increased with high tertiles of the CAR (MACCE: 8.7 vs 10.5 vs 12.3%, log-rank P < .001; MI: 3.3 vs 4.0 vs 4.7%, long-rank P = .015). Cox regression analysis suggested that CAR was an independent risk factors for MACCE (HR per standard deviation (SD) increase: 1.07, 95% CI, 1.01–1.14, P = .024), and MI (HR per SD increase: 1.11, 95% CI, 1.01–1.22, P = .028). In conclusion, the CAR is an independent predictor of MACCE and MI in CHD patients.
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Yang et al. (2022) conducted a cohort in Coronary heart disease (CHD) (n=9,375). High-sensitivity C-reactive protein to albumin ratio (CAR) vs. Lower CAR tertiles was evaluated on Major adverse cardiovascular and cerebrovascular events (MACCE) (HR 1.07, 95% CI 1.01-1.14, p=.024). A higher high-sensitivity C-reactive protein to albumin ratio was associated with an increased risk of MACCE (HR per SD increase 1.07; 95% CI 1.01-1.14; P=0.024) in CHD patients undergoing PCI.
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