Population
Isolated and blood-perfused canine atrial and ventricular muscle preparations paced at 1.5-2.5 Hz
Design
Preclinical
Authors
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These isolated findings should not guide clinical inotrope use; they leave open chamber-specific purine effects for intact models.
This preclinical study demonstrates differential inotropic responses of canine atrial and ventricular muscle to various purine compounds, highlighting adenosine's negative inotropic effect in atria versus positive effects in ventricles.
Chiba et al. (1981) studied this question.
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