Key result
Adenosine inhibits isoprenaline-induced increases in myocardial contractility but not those caused by insulin.
Why the study?
Does adenosine inhibit the positive inotropic effects of isoprenaline and insulin in vivo?
Does adenosine inhibit the positive inotropic effects of isoprenaline and insulin in vivo?
Adenosine inhibits beta-adrenergic-mediated increases in myocardial contractility in vivo but does not affect inotropic responses acting independently of adenylate cyclase, such as those from insulin.
Answers are grounded in this paper and cite their sources.
Adenosine's selective effects on contractility remain preclinical; leaves open translation to human inotropic therapies.
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Law et al. (1991) studied this question. Adenosine vs. Saline was evaluated on Myocardial contractility (slope of the end systolic pressure-dimension relationship [Ees] and left ventricular dP/dtmax). Adenosine inhibited the increases in myocardial contractility caused by isoprenaline, but not those caused by insulin in vivo.
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