Key result
Mild gestational impaired glucose tolerance was associated with lower left and right fetal ventricular myocardial performance indices by late gestation compared to controls (P=0.002 and P=0.0008).
Why the study?
Does mild gestational impaired glucose tolerance affect fetal myocardial performance compared to normal pregnancies?
Population
81 pregnant women, including 37 with mild gestational impaired glucose tolerance and 44 controls.
Comparison
Mild gestational impaired glucose tolerance (GIGT) vs Normal pregnancies (controls)
Design
Cohort
Follow-up
Up to 34-37 weeks of gestation
Authors
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Mild GIGT-associated lower fetal MPI warrants no practice change; leaves open whether this signals clinically relevant cardiac effects or long-term outcomes.
Observational (n=81)
Does mild gestational impaired glucose tolerance affect fetal myocardial performance compared to normal pregnancies?
p-value: p=0.002 and 0.0008
Fetuses of women with mild GIGT do not develop the ventricular hypertrophy or diastolic dysfunction typical of diabetic pregnancies, but do exhibit a decreased myocardial performance index late in gestation.
Wong et al. (2007) conducted an observational in Mild gestational impaired glucose tolerance (n=81). Mild gestational impaired glucose tolerance vs. Controls was evaluated on Left and right ventricular myocardial performance index (MPI) at late gestation (p=0.002 and 0.0008). Mild gestational impaired glucose tolerance was associated with lower left and right fetal ventricular myocardial performance indices by late gestation compared to controls (P=0.002 and P=0.0008).
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