Key result
Gestational diabetes mellitus was associated with a significantly higher fetal Myocardial Performance Index compared to pregnancies without glucose intolerance (P=0.000).
Why the study?
The authors sought to evaluate fetal cardiac functions with the Myocardial Performance Index in gestational diabetes mellitus.
Does gestational diabetes mellitus impair fetal cardiac functions as measured by Myocardial Performance Index compared to normal pregnancy?
Observational (n=70)
Does gestational diabetes mellitus impair fetal cardiac functions as measured by Myocardial Performance Index compared to normal pregnancy?
p-value: p=0.000
Gestational diabetes mellitus is associated with impaired fetal cardiac function as indicated by a significantly higher Myocardial Performance Index.
GDM associated with fetal cardiac impairment; hypothesis-generating and should not yet change practice.
BACKGROUND: We aimed to evaluate the fetal cardiac functions with Myocardial Performance Index (MPI) in gestational diabetes mellitus (GDM). METHODS: In this study, 35 patients who were diagnosed with GDM, and 35 pregnant without glucose intolerance and their babies were evaluated. Fetal echocardiographic, biometric measurements, umbilical artery pulsatility indices (UAPI) and ductus venosus pulsatility indices (DVPI) measurements were performed to evaluate fetal well-being between the groups. RESULTS: There was no statistically significant difference between the groups in terms of UAPI, DVPI, systolic functions, the mode of delivery and 5-minute APGAR scores (P=0.849, P=0.485, P=0.770, P=0.060, P=0.587). There was statistically significant difference between the isovolumetric relaxation time and isovolumetric contraction time of groups (P=0.006, P=0.03). The MPI results were statistically different between the groups (P=0.000). Postpartum need for hospitalization was more frequently observed in GDM than the control group (P=0.014). CONCLUSIONS: MPI, which is independent of the ventricular anatomy and fetal heart rate, showing both diastolic and systolic functions, was found significantly higher in GDM. We recommend performing MPI measurement routinely to fetal cardiac functions in GDM.
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Alkan et al. (2021) conducted an observational in Gestational diabetes mellitus (n=70). Gestational diabetes mellitus vs. Pregnant women without glucose intolerance was evaluated on Myocardial Performance Index (MPI) (p=0.000). Gestational diabetes mellitus was associated with a significantly higher fetal Myocardial Performance Index compared to pregnancies without glucose intolerance (P=0.000).
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