Key result
Gestational diabetes mellitus was associated with a significantly higher mean fetal modified myocardial performance index compared to healthy pregnancies (0.41 vs 0.38, p=0.002).
Why the study?
Gestational diabetes can affect myocardial function and alter modified myocardial performance index (Mod-MPI) values, but its utility in evaluating fetal cardiac function in GDM is unclear.
Does gestational diabetes mellitus alter fetal cardiac function as measured by the modified myocardial performance index compared to healthy pregnancies?
Case-Control (n=60)
No
Does gestational diabetes mellitus alter fetal cardiac function as measured by the modified myocardial performance index compared to healthy pregnancies?
Absolute Event Rate: 0.41% vs 0.38%
p-value: p=0.002
Fetuses of mothers with gestational diabetes mellitus exhibit higher modified myocardial performance index values, suggesting subclinical alterations in fetal cardiac function.
Higher fetal Mod-MPI in GDM; leaves open its clinical utility as a cardiac marker pending larger prospective studies.
Objectives The modified myocardial performance index (Mod‐MPI) is a new technique that is used to assess myocardial function. Gestational Diabetes can affect myocardial function and may lead to change Mod –MPI value. We aimed to evaluate fetal cardiac function with Mod-MPI in pregnant with GDM and compare with healthy pregnant. Material and Methods Totally 60 pregnant; 30 with GDM and 30 without disease were included into this prospective case control study. Demographic characteristics of the study group were recorded. Mod-MPI and obstetric Doppler parameters were calculated for each fetus by an experienced perinatologist. The results of the two groups were compared. Results There was no difference in demographic characteristics terms of age, parity and BMI. The mean Mod-MPI value was found significantly higher in pregnant with GDM when compared with healthy pregnant. The obstetric Doppler parameters were found similar between groups. Conclusion The utility of the Mod‐MPI in GDM pregnant is unclear in literature. Future prospective studies with larger number of cases are needed to to evaluate the utility of the Mod‐MPI as a predictor of cardiac function in fetuses of GDM mothers.
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Oğuz et al. (2023) conducted a case-control in Gestational Diabetes Mellitus (n=60). Gestational Diabetes Mellitus vs. Healthy pregnant women without GDM was evaluated on Fetal left ventricle modified myocardial performance index (Mod-MPI) (p=0.002). Gestational diabetes mellitus was associated with a significantly higher mean fetal modified myocardial performance index compared to healthy pregnancies (0.41 vs 0.38, p=0.002).
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