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August 1, 2003Open Access

Plasma brain natriuretic peptide and the evaluation of volume overload in infants and children with congenital heart disease.

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Why the study?

Does plasma BNP level correlate with volume overload and disease severity in infants and children with congenital heart disease?

Population

407 infants and children, comprising 253 normal children, 91 with ventricular septal defect, 29 with patent…

Comparison

Measurement of plasma brain natriuretic peptide… vs Normal children and healthy neonates

Design

Cross-sectional

Authors

YKYuko KuniiOkayama UniversityMKMasahiro KamadaHiroshima City Asa Citizens HospitalSOShinichi OhtsukiOkayama University Hospital

Discussion

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Implication

BNP may support noninvasive shunt assessment in pediatric VSD/PDA; leaves open its role in guiding surgical timing pending prospective validation.

Structured PICO

Does plasma BNP level correlate with volume overload and disease severity in infants and children with congenital heart disease?

P
Population
407 infants and children, comprising 253 normal children (including 11 normal neonates), 91 with ventricular septal defect (VSD), 29 with patent ductus arteriosus (PDA), and 34 with atrial septal defect (ASD).
I
Intervention
Measurement of plasma brain natriuretic peptide (BNP) levels
C
Comparator
Normal children and healthy neonates
O
Outcome
Correlation of BNP levels with disease severity markers including Qp/Qs, LVEDV, peak RVP/LVP, and RVEDVsurrogate

Plasma BNP levels correlate well with disease severity and volume overload in children with congenital heart disease, potentially aiding in the evaluation of surgical indications.

Cite This Study

Kunii et al. (2003) studied this question.

synapsesocial.com/papers/6a89b413273d243e4992e770https://doi.org/10.18926/amo/32809

Topics

EchocardiographyCongenital heart disease adults
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma brain natriuretic peptide concentrations in healthy children from birth to adolescence: marked and rapid increase after birth1995 · 116 citations
  2. 2Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide.1991 · 1,363 citations
  3. 3Plasma cardiac natriuretic peptide determination as a screening test for the detection of patients with mild left ventricular impairment.1996 · 155 citations
  4. 4Localization and mechanism of secretion of B-type natriuretic peptide in comparison with those of A-type natriuretic peptide in normal subjects and patients with heart failure.1994 · 1,346 citations
  5. 5Right and left ventricular volume characteristics in children with pulmonary stenosis and intact ventricular septum.1976 · 130 citations