Why the study?
The study aimed to evaluate the diagnostic value and correlation of plasma brain natriuretic peptide levels with hemodynamic, ECG, and echocardiographic data in pediatric congenital heart disease.
Does plasma BNP level serve as a reliable diagnostic marker and correlate with clinical severity in children with congenital heart disease?
Population
60 children aged 2 months to 10 years
Comparison
40 cases with CHD vs 20 controls
Design
Observational prospective study
Key result
Plasma brain natriuretic peptide levels at a cutoff of >7690 pg/ml demonstrated a sensitivity of 93.3% and specificity of 76% for diagnosing congenital heart disease in children.
Authors
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May support BNP for CHD diagnosis in children; extends low-certainty evidence from 101 studies but leaves open routine use pending validation.
Observational (n=60)
No
Does plasma BNP level serve as a reliable diagnostic marker and correlate with clinical severity in children with congenital heart disease?
Plasma BNP is a highly sensitive diagnostic marker that correlates with clinical severity and reduced ejection fraction in children with congenital heart disease.
El-Masry et al. (2026) conducted an observational in Congenital heart disease (n=60). Plasma brain natriuretic peptide (BNP) measurement vs. Healthy controls was evaluated on Diagnostic value of plasma BNP levels. Plasma brain natriuretic peptide levels at a cutoff of >7690 pg/ml demonstrated a sensitivity of 93.3% and specificity of 76% for diagnosing congenital heart disease in children.