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June 1, 1996Ultrasound in Obstetrics and Gynecology

Cardiac functional changes in the human fetus in the late first and early second trimesters

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Population

52 women at 10-20 weeks of normal gestation (fetuses)

Design

Cross-sectional

Authors

ISI. P. van SplunderErasmus MCJWJ. W. WladimiroffErasmus University Rotterdam

Discussion

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Implication

Requires gestational age-specific fetal cardiac reference ranges now; leaves open links to later outcomes.

Structured PICO

P
Population
52 women at 10-20 weeks of normal gestation (fetuses)
O
Outcome
Transmitral and ascending aortic flow velocity waveforms, filling and ejection time, isovolumic contraction and relaxation timesurrogate

Fetal cardiac function undergoes significant gestational age-related changes during the late first and early second trimesters, including increased flow velocities and filling times.

Cite This Study

Splunder et al. (1996) studied this question.

synapsesocial.com/papers/6a89b414de8e7079c6f7e1a2https://doi.org/10.1046/j.1469-0705.1996.07060411.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Doppler study of the embryonic heart in normal pregnant women2007 · 41 citations
  2. 2Changes in intracardiac blood flow velocities and right and left ventricular stroke volumes with gestational age in the normal human fetus: a prospective Doppler echocardiographic study.1986 · 251 citations
  3. 3Echocardiographic assessment of ventricular filling pressure during the second and third trimesters of gestation2000 · 23 citations
  4. 4First-Trimester Fetal Cardiac Function2008 · 27 citations
  5. 5Fetal cardiac development and hemodynamics in the first trimester1999 · 77 citations