Key result
Although the majority of included studies suggest a positive association between celiac disease and dilated cardiomyopathy, conflicting results exist, highlighting the need for further research.
Why the study?
Cardiac manifestations are infrequently reported in association with celiac disease, but a clear link has not been established.
Is celiac disease associated with dilated cardiomyopathy and other cardiac manifestations?
Systematic Review (n=19)
Is celiac disease associated with dilated cardiomyopathy and other cardiac manifestations?
Celiac disease appears to be associated with dilated cardiomyopathy and other cardiovascular manifestations in the majority of studies, suggesting a potential role for active cardiac screening in this population.
Answers are grounded in this paper and cite their sources.
Inconsistent evidence links celiac disease to dilated cardiomyopathy; leaves open need for prospective studies before screening or management changes.
BACKGROUND: Cardiac manifestations are infrequently reported in association with celiac disease, but clear link has not been established. The aim of this study was to explore the connection of dilated cardiomyopathy in celiac disease. This systematic review also provides a comprehensive overview of the association between celiac disease and various cardiac manifestations with pathophysiology and management. MAIN BODY: We searched PubMed, Cochrane Library, Google Scholar, Embase, Scopus, and Springer nature databases through June 4th 2023 for preferred studies related to our topic using MeSH and Regular keywords. After comprehensive search analysis, data extraction and quality appraisal 19 studies were included in the study. Although results varied across studies, majority of the studies revealed a positive link. Notably, some studies suggested an association between celiac disease and dilated cardiomyopathy, while others did not. These discrepancies could be attributed to differences in methodologies, study populations, and regional variations. Several studies have shown the association of various cardiac manifestations in celiac disease. CONCLUSION: Although dilated cardiomyopathy is associated with celiac disease in majority of the studies, there are also studies that conflict with the association. The complex relationship between celiac disease and cardiovascular manifestations potentiates the need for further research with standardized methodologies, larger sample sizes, and consideration of regional variations. Such insights are vital for improving clinical practice by establishing preventive strategies, active screening, early diagnosis, mitigating risks which helps in optimizing cardiovascular health in individuals with celiac disease.
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Yadavalli et al. (2024) conducted a systematic review in Celiac disease and dilated cardiomyopathy (n=19). Celiac disease vs. Individuals without celiac disease was evaluated on Association between celiac disease and dilated cardiomyopathy. Although the majority of included studies suggest a positive association between celiac disease and dilated cardiomyopathy, conflicting results exist, highlighting the need for further research.
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