Key result
In an experimental model of septic shock, isolated heart rate reduction by ivabradine decreased heart rate but did not improve cardiac function, vascular responsiveness, or inflammatory pathways.
Why the study?
Does ivabradine improve cardiac and vascular function or inflammatory pathways in a rat model of septic shock?
RCT (n=24)
Randomly allocated
Does ivabradine improve cardiac and vascular function or inflammatory pathways in a rat model of septic shock?
In a rat model of septic shock, isolated heart rate reduction with ivabradine did not improve hemodynamics, vascular responsiveness, or inflammatory markers.
No takes yet. Share an insight, caveat, or question.
No benefit from isolated heart rate reduction in this septic shock model; leaves open any clinical role for ivabradine.
Wei et al. (2016) conducted an RCT in Peritonitis-induced septic shock (n=24). Ivabradine vs. CLP without ivabradine was evaluated on Cardiovascular function and inflammatory pathways. In an experimental model of septic shock, isolated heart rate reduction by ivabradine decreased heart rate but did not improve cardiac function, vascular responsiveness, or inflammatory pathways.
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