Key result
Melatonin administration exerts an infarct size limiting effect, antiapoptotic and antiarrhythmic effects, and enhances antioxidant activity of the heart during myocardial ischemia reperfusion injury.
Why the study?
Does melatonin reduce myocardial ischemia reperfusion injury in experimental models?
Does melatonin reduce myocardial ischemia reperfusion injury in experimental models?
Melatonin demonstrates potential cardioprotective effects against myocardial ischemia-reperfusion injury in experimental models through its antioxidant, antiapoptotic, and antiarrhythmic properties.
Extends preclinical evidence for melatonin's cardioprotective effects; leaves open translation to human ischemia-reperfusion injury.
A lot of mechanisms play major role in the myocardial ischemia reperfusion injury (MI/R), especially reactive oxygen species (ROS) which they formed rapidly when molecular oxygen enters into the cell. Melatonin, major hormone of the pineal gland, is very strong antioxidant and free radical scavenger effects. Besides, melatonin plays an important role in the regulation of various body functions including circadien sleep rhythms, blood pressure, oncogenesis, retinal function, and immunity. It can be possible to say that oxidative stress occurs during MI/R and melatonin administration exerts an infarct size limiting effect, antiapoptic, antiarryhtmic effects , enhances antioxidant activity of the heart. [Med-Science 2014; 3(4.000): 1766-80]
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Parlakpınar et al. (2014) conducted a review in Myocardial ischemia reperfusion injury. Melatonin was evaluated. Melatonin administration exerts an infarct size limiting effect, antiapoptotic and antiarrhythmic effects, and enhances antioxidant activity of the heart during myocardial ischemia reperfusion injury.
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