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March 3, 2026Medicine Science | International Medical JournalOpen Access

Incidence of malignancy in appendiceal surgical specimens: A retrospective single-center study

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Authors

EAEnes AgirmanFBFurkan BingolRPRifat Peksoz

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Overview

Retrospective analysis reveals incidences of malignancy in appendiceal specimens, highlighting the need for thorough examination.

Key Points

  • The aim is to analyze the incidence of malignancy in appendiceal specimens from patients undergoing appendectomy.
  • Retrospective analysis of 2802 adult patients who had an appendectomy for suspected acute appendicitis.
  • Evaluation of demographics, surgical approach, histopathological findings, and tumor characteristics.
  • Data collection spanned from January 2015 to May 2025.
  • 0.7% of patients diagnosed with neuroendocrine tumors (NETs), 0.4% with low-grade appendiceal mucinous neoplasms (LAMNs), and 0.1% with adenocarcinomas.
  • Mean age of patients with NETs was 33.5 years, while those with LAMNs and adenocarcinomas were older than 50 years.
  • Most NETs were Grade 1 and had a Ki-67 index of less than 3%.
  • LAMNs showed no invasive features but had acellular mucin in deeper layers.
  • Adenocarcinoma cases exhibited deep invasion, positive margins, and lymphovascular involvement.

Cite This Study

Agirman et al. (2026) studied this question.

synapsesocial.com/papers/69a67eb2f353c071a6f0a213https://doi.org/10.5455/medscience.2025.06.176
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Incidental appendiceal neoplasms: Single-centre results2023 · 3 citations
  2. 2Retrospective analysis of the incidence of appendiceal neoplasm and malignancy in patients treated for suspected acute appendicitis2024 · 10 citations
  3. 3Histopathological Spectrum of Appendicectomy Specimens: A 1-year Retrospective Study in a Tertiary Care Center2026
  4. 4Clinicopathological Profile and Management of Appendiceal Neoplasm: An Observational Study2025
  5. 5The risk of neoplasms in appendiceal abscess: what emergency surgeons should know2026