What question did this study set out to answer?

To determine the incidence and predictors of neoplastic disease in patients with clinically abnormal appendices.

February 22, 2026Annals of Surgical Oncology

Incidence and Predictors of Neoplastic Diagnosis in Patients with a Clinically Abnormal Appendix

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Authors

TGTina GowdaMemorial Sloan Kettering Cancer Center NANicole AguirreMemorial Sloan Kettering Cancer Center MMMostafa MohamedMemorial Sloan Kettering Cancer Center

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Implication

Analysis reveals high neoplastic disease incidence in patients with abnormal appendices on imaging or endoscopy, suggesting diagnostic appendectomy as vital.

Key Points

To determine the incidence and predictors of neoplastic disease in patients with clinically abnormal appendices.
Review of patients undergoing diagnostic appendectomy following abnormal endoscopy or imaging findings at a cancer center (2011–2021)
Exclusion of acute appendicitis without suspicious lesions, peritoneal carcinomatosis, or known malignancy
Comparison of radiographic, biochemical, and colonoscopic findings between neoplastic and non-neoplastic cases.
Neoplastic disease found in 68 out of 132 patients (52%)
Higher incidence associated with cystic mass (77%), calcifications (75%), and dilated appendix (63%)
Low incidence (0%) in cases of inflammation without cystic mass
Defined risk groups: high (77% neoplasm), moderate (42%), low (0%)

Cite This Study

Gowda et al. (2026) studied this question.

synapsesocial.com/papers/699a534bfdaf4e3c1268ed44 https://doi.org/10.1245/s10434-026-19177-0

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Implication

Analysis reveals high neoplastic disease incidence in patients with abnormal appendices on imaging or endoscopy, suggesting diagnostic appendectomy as vital.

Incidence and Predictors of Neoplastic Diagnosis in Patients with a Clinically Abnormal Appendix

Discussion

Member takes

Implication

Key Points

Cite This Study

Incidence and Predictors of Neoplastic Diagnosis in Patients with a Clinically Abnormal Appendix

Discussion

Member takes

Implication

Key Points

Cite This Study

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