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May 8, 2026Frontiers in OncologyOpen Access

The risk of neoplasms in appendiceal abscess: what emergency surgeons should know

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Authors

GMGiulia MontoriMPMauro PoddaAGAlessio GIORDANO

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Overview

Narrative review outlines neoplasm risks in appendicitis with abscess, highlighting management implications.

Key Points

  • This review aims to examine the incidence and characteristics of neoplasms associated with appendiceal abscess in patients, particularly in older adults.
  • Conducted a literature search in MEDLINE and the Cochrane Central Register from inception to November 2025.
  • Included randomized controlled trials, cohort studies, and case–control studies relevant to complicated acute appendicitis.
  • Synthesized data qualitatively through a narrative approach.
  • Incidence of appendiceal neoplasms is below 2% in uncomplicated acute appendicitis, but increases to 10–15% with periappendiceal abscess.
  • Neuroendocrine tumors are commonly found in uncomplicated appendicitis; low-grade mucinous neoplasms are predominant in abscess cases.
  • Age above 35–40 years significantly elevates the risk of neoplasia, while pediatric studies indicate a negligible risk of malignancy.

Cite This Study

Montori et al. (2026) studied this question.

synapsesocial.com/papers/69fd7cd4bfa21ec5bbf05b37https://doi.org/10.3389/fonc.2026.1767622
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interval Appendectomy after Conservative Treatment of an Appendiceal Mass2006 · 85 citations
  2. 2The incidence of right-sided colon cancer in patients aged over 40 years with acute appendicitis: A systematic review and meta-analysis2020 · 27 citations
  3. 3Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines2020 · 1,459 citations
  4. 4German S2k-guideline on diagnostics, treatment and surveillance of low-grade appendiceal mucinous neoplasms (LAMN)2025 · 6 citations
  5. 5Incidence rate and histology of appendiceal neoplasms in complicated versus uncomplicated appendicitis: A meta-analysis and systematic review2023 · 24 citations