Key result
Captopril prevented left ventricular hypertrophy in continuous light-induced hypertension, while melatonin significantly reduced fibrosis.
Why the study?
Does captopril or melatonin prevent hypertension and cardiovascular remodeling in rats exposed to continuous light?
Does captopril or melatonin prevent hypertension and cardiovascular remodeling in rats exposed to continuous light?
In a rat model of continuous light-induced hypertension, captopril prevents LV hypertrophy while melatonin specifically reduces cardiac fibrosis, suggesting complementary protective effects.
Should not change practice; leaves open complementary remodeling effects in light-induced hypertension models pending human validation.
Exposure of rats to continuous light attenuates melatonin production and results in hypertension development. This study investigated whether hypertension induced by continuous light (24 hours/day) exposure induces heart and aorta remodelling and if these alterations are prevented by melatonin or angiotensin converting enzyme inhibitor captopril. Four groups of 3-month-old male Wistar rats (10 per group) were treated as follows for six weeks: untreated controls, exposed to continuous light, light-exposed, and treated with either captopril (100 mg/kg/day) or melatonin (10 mg/kg/day). Exposure to continuous light led to hypertension, left ventricular (LV) hypertrophy and fibrosis, and enhancement of the oxidative load in the LV and aorta. Increase in systolic blood pressure by continuous light exposure was prevented completely by captopril and partially by melatonin. Both captopril and melatonin reduced the wall thickness and cross-sectional area of the aorta and reduced the level of oxidative stress. However, only captopril reduced LV hypertrophy development and only melatonin reduced LV hydroxyproline concentration in insoluble and total collagen in rats exposed to continuous light. In conclusion, captopril prevented LV hypertrophy development in the continuous light-induced hypertension model, while only melatonin significantly reduced fibrosis. This antifibrotic action of melatonin may be protective in hypertensive heart disease.
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Šimko et al. (2014) studied Hypertension induced by continuous light (n=40). Captopril or Melatonin vs. Untreated controls and light-exposed controls was evaluated on Systolic blood pressure, left ventricular hypertrophy, fibrosis, and oxidative stress. Captopril prevented left ventricular hypertrophy in continuous light-induced hypertension, while melatonin significantly reduced fibrosis.
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