Key result
The SALVO analytical framework successfully quantified drug-induced calcium signal perturbations in human stem cell-derived cardiomyocytes, ranking cytotoxicity in agreement with known arrhythmogenic liabilities.
The SALVO analytical framework successfully profiles drug-induced calcium signal perturbations in human stem cell-derived cardiomyocytes, providing a mechanistically agnostic system for early-stage drug screening of arrhythmogenic liabilities.
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May aid early arrhythmogenicity screening in drug development; leaves open clinical translation from stem cell models.
Lewis et al. (2014) studied this question. SALVO analytical framework was evaluated on Drug-induced perturbations in the calcium signaling fingerprint. The SALVO analytical framework successfully quantified drug-induced calcium signal perturbations in human stem cell-derived cardiomyocytes, ranking cytotoxicity in agreement with known arrhythmogenic liabilities.
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