July 13, 2006Anesthesia & Analgesia

Neuronal Injury After Repeated Brief Cardiac Arrests During Internal Cardioverter Defibrillator Implantation Is Associated With Deterioration of Cognitive Function

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Why the study?

Does internal cardioverter defibrillator implantation (with repeated brief cardiac arrests) cause neurocognitive dysfunction and neuronal injury compared to pacemaker insertion in patients undergoing device placement?

Population

42 patients undergoing internal cardioverter defibrillator (ICD) (n=21) or pacemaker (PM) insertion (n=21).

Comparison

Internal cardioverter defibrillator implantation. vs Pacemaker (PM) insertion.

Design

Cohort

Follow-up

up to 24 hours postoperatively

Authors

MWManuela WeiglMedical University of Vienna AMAndrea MoritzGoethe University Frankfurt BSBarbara SteinlechnerMedical University of Vienna

Discussion

Member takes

Implication

Suggests neurocognitive risk after ICD implantation; hypothesis-generating and should not yet change practice.

Structured PICO

Population

42 patients undergoing internal cardioverter defibrillator (ICD) (n=21) or pacemaker (PM) insertion (n=21).

Intervention

Internal cardioverter defibrillator (ICD) implantation (involving repeated brief cardiac arrests).

Comparator

Pacemaker (PM) insertion.

Outcome

Degree of neurocognitive dysfunction (measured by Mini Mental State Examination, Trailmaking A test, forward and backward Digit Span tests, P300 latencies) and extent of neuronal injury (measured by serum neuron-specific enolase [NSE] before, at the end of, and 2, 6, and 24 h after surgery).surrogate

ICD implantation, which involves brief periods of global brain ischemia, is associated with measurable neuronal injury and deteriorating neurocognitive function compared to pacemaker insertion.

Cite This Study

Weigl et al. (2006) studied this question.

synapsesocial.com/papers/6a89b69f755d28965dfd51d4 https://doi.org/10.1213/01.ane.0000226088.59744.3e

Topics

Cardiac device therapy

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Neuronal Injury After Repeated Brief Cardiac Arrests During Internal Cardioverter Defibrillator Implantation Is Associated With Deterioration of Cognitive Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Neuronal Injury After Repeated Brief Cardiac Arrests During Internal Cardioverter Defibrillator Implantation Is Associated With Deterioration of Cognitive Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider