August 1, 2004Platelets

Clopidogrel (Plavix®) and cardiac surgical patients: implications for platelet function monitoring and postoperative bleeding

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Why the study?

How does preoperative clopidogrel affect platelet function monitoring and postoperative bleeding in coronary bypass surgery patients?

Population

18 coronary bypass surgery patients receiving clopidogrel preoperatively, alongside an in vitro model of ADP…

Design

Cohort

Follow-up

postoperative period

Authors

KTKenichi A. TanakaUniversity of Maryland, Baltimore FSFania SzlamUniversity of Maryland, Baltimore AKAndrew B. KellyScripps Research Institute

Discussion

Member takes

Implication

Standard TEG MA may miss clopidogrel effects pre-CPB; leaves open whether ADP-specific assays better predict bleeding risk in observational data.

Structured PICO

How does preoperative clopidogrel affect platelet function monitoring and postoperative bleeding in coronary bypass surgery patients?

Population

18 coronary bypass surgery patients receiving clopidogrel preoperatively, alongside an in vitro model of ADP inhibition.

Intervention

Preoperative clopidogrel (clinical phase) and 5'-p-fluorosulfonylbenzoyladenosine (FSBA) 80 microM (in vitro phase).

Outcome

Platelet function assessed by thrombelastography (TEG), platelet aggregometry, and whole blood aggregation, as well as postoperative bleeding and platelet transfusion requirements.surrogate

Standard TEG maximum amplitude does not reliably detect clopidogrel-induced platelet inhibition preoperatively, necessitating specific ADP-activated tests to predict the high risk of postoperative bleeding in these patients.

Cite This Study

Tanaka et al. (2004) studied this question.

synapsesocial.com/papers/6a89b86e755d28965dfd5237 https://doi.org/10.1080/09537100410001710236

Topics

Women and heart disease

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Implication

Standard TEG MA may miss clopidogrel effects pre-CPB; leaves open whether ADP-specific assays better predict bleeding risk in observational data.

Clopidogrel (Plavix®) and cardiac surgical patients: implications for platelet function monitoring and postoperative bleeding

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Clopidogrel (Plavix®) and cardiac surgical patients: implications for platelet function monitoring and postoperative bleeding

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider