What question did this study set out to answer?

To review the signaling pathways and receptor mechanisms responsible for triggering integrin alphaIIbbeta3 activation and driving platelet aggregation.

September 1, 2001Current Opinion in Hematology

Mechanisms of platelet aggregation

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BSBrian SavageThe University of Queensland MCMarco CattaneoVascular Medicine ZRZaverio M. RuggeriGeneral / Preventive / Lipids

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Implication

This review highlights recent advances in understanding the receptor activation and intracellular signaling mechanisms that drive platelet aggregation.

Key Points

To review the signaling pathways and receptor mechanisms responsible for triggering integrin alphaIIbbeta3 activation and driving platelet aggregation.
Literature synthesis of experimental and molecular findings regarding platelet surface receptors and intracellular signaling pathways.
Platelet aggregation depends on agonist-induced receptor activation that transmits intracellular signals to convert integrin alphaIIbbeta3 into a high-affinity state.
Receptors for collagen, von Willebrand factor, thrombin, and adenosine diphosphate provide distinct yet convergent pathways that regulate platelet adhesion and thrombus formation.

Cite This Study

Savage et al. (2001) studied this question.

synapsesocial.com/papers/6a89b86e755d28965dfd523d https://doi.org/10.1097/00062752-200109000-00002

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Implication

This review highlights recent advances in understanding the receptor activation and intracellular signaling mechanisms that drive platelet aggregation.

Mechanisms of platelet aggregation

Discussion

Member takes

Implication

Key Points

Cite This Study

Mechanisms of platelet aggregation

Discussion

Member takes

Implication

Key Points

Cite This Study

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