Population
Mice that express lipoprotein lipase (LPL) exclusively in muscle (LPL-deficient in adipose tissue)
Comparison
LPL deficiency in adipose tissue (genetic model) vs Control mice with normal LPL expression in…
Design
Preclinical
Authors
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Hypothesis-generating for compensatory lipogenesis in LPL deficiency; leaves open human relevance.
In the absence of LPL in adipose tissue, lipogenesis is activated through increased SREBP-1 expression and processing triggered by decreased availability of nutrition-derived fatty acids.
Wagner et al. (2004) studied this question.
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