What question did this study set out to answer?

To determine whether vaccine-induced protection against simian immunodeficiency virus is driven by virus-specific immunity or by immune responses against host cell substrate antigens.

January 1, 1993AIDS Research and Human Retroviruses

Studies on the Specificity of the Vaccine Effect Elicited by Inactivated Simian Immunodeficiency Virus

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To determine whether vaccine-induced protection against simian immunodeficiency virus is driven by virus-specific immunity or by immune responses against host cell substrate antigens.
Immunized macaques with inactivated, partially purified SIVmac or HIV-1 prepared on human C8166 T-cell lines.
Challenged vaccinated macaques intravenously with homologous and heterologous SIV strains propagated in either human cells or monkey peripheral blood mononuclear cells.
Evaluated post-vaccination serum for anti-cell antibody responses and specific reactivity against cellular antigens.
Vaccination with human-cell-grown SIVmac or HIV-1 protected macaques against challenge with human-cell-grown SIV, but failed to protect against challenge with monkey PBMC-grown SIVmac.
All vaccinated macaques generated high titers of anti-cell antibodies, demonstrating major reactivity to MHC class I antigens and a 70-kD protein detectable under nonreducing conditions.

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Implication

Preclinical study reveals vaccine protection against SIV is mediated by human host cell antigens in macaques, indicating xenoimmunization drives efficacy.

Cite This Study

Cranage et al. (1993) studied this question.

synapsesocial.com/papers/6a89ba676099c687143343a2 https://doi.org/10.1089/aid.1993.9.13

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Implication

Preclinical study reveals vaccine protection against SIV is mediated by human host cell antigens in macaques, indicating xenoimmunization drives efficacy.

Studies on the Specificity of the Vaccine Effect Elicited by Inactivated Simian Immunodeficiency Virus

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Discussion

Implication

Cite This Study

Studies on the Specificity of the Vaccine Effect Elicited by Inactivated Simian Immunodeficiency Virus

Key Points

Discussion

Implication

Cite This Study

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