Key result
Sera from macaques immunized with whole inactivated SIV preparations consistently reacted with normal human cells and correlated with protection, unlike sera from other vaccine types.
Population
More than 200 sera from macaques immunized with several different vaccine preparations
Comparison
Whole inactivated SIV preparations vs Sera from normal animals, animals chronically…
Design
Preclinical
Authors
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Anti-cellular antibodies may mediate SIV protection in macaques; leaves open translation to human HIV vaccine efficacy.
Immunization of macaques with whole inactivated SIV induces anti-human cell antibodies that correlate with protection.
Langlois et al. (1992) studied SIV immunization (n=200). Whole inactivated SIV vaccine preparations vs. Normal animals, chronically infected animals, or recombinant viral subunit vaccines was evaluated on Reactivity with normal human cells. Sera from macaques immunized with whole inactivated SIV preparations consistently reacted with normal human cells and correlated with protection, unlike sera from other vaccine types.
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