December 1, 1997Diabetes

Tumor Necrosis Factor-α Induces Apoptosis of Human Adipose Cells

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Population

Cultured human preadipocytes and mature adipocytes in explant cultures

Comparison

Human TNF-alpha at varying concentrations for up… vs Control cultures

Design

Preclinical

Follow-up

up to 24 h

Authors

JPJohannes B. PrinsUniversity of Udine CNCarola U. NieslerUmkhuseli Innovation and Research Management CWClay WinterfordQIMR Berghofer Medical Research Institute

Discussion

Member takes

Implication

TNF-α-induced adipocyte apoptosis may limit obesity; hypothesis-generating in animal models and should not yet change practice.

Structured PICO

Population

Cultured human preadipocytes and mature adipocytes in explant cultures

Intervention

Human TNF-alpha at varying concentrations for up to 24 h

Comparator

Control cultures

Outcome

Apoptosis assessed using morphological (histology, nuclear morphology following acridine orange staining, electron microscopy) and biochemical (internucleosomal DNA cleavage, annexin V staining) criteriasurrogate

TNF-alpha induces apoptosis in human preadipocytes and adipocytes in vitro, suggesting a mechanism by which it may limit the development or extent of obesity.

Cite This Study

Prins et al. (1997) studied this question.

synapsesocial.com/papers/6a89bee641f4089922bd72ba https://doi.org/10.2337/diab.46.12.1939

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Tumor Necrosis Factor-α Induces Apoptosis of Human Adipose Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Tumor Necrosis Factor-α Induces Apoptosis of Human Adipose Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider