January 1, 2004Journal of Medical GeneticsOpen Access

Clinical and genetic characteristics of α cardiac actin gene mutations in hypertrophic cardiomyopathy

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Population

206 consecutive Caucasian probands with hypertrophic cardiomyopathy defined by unexplained myocardial…

Design

Cohort

Authors

JMJens MogensenHeart Failure / Cardiomyopathy

Discussion

Member takes

Implication

Provides European ACTC-HCM cohort data; leaves open prognostic and management implications pending validation.

Structured PICO

Population

206 consecutive Caucasian probands with hypertrophic cardiomyopathy (HCM) defined by unexplained myocardial hypertrophy (maximal left ventricular wall thickness ╾13 mm or major ECG abnormalities) from Germany (n=146) and Denmark (n=60), as well as their relatives.

Intervention

Mutation analysis of the ACTC (α cardiac actin) gene

Outcome

Clinical and genetic characteristics of ACTC mutations

This study aims to describe the clinical and genetic characteristics of ACTC mutations in a European cohort of patients with hypertrophic cardiomyopathy.

Cite This Study

Jens Mogensen (2004) studied this question.

synapsesocial.com/papers/6a89c0a0ab4588dbccfb99a0 https://doi.org/10.1136/jmg.2003.010447

Topics

Hypertrophic cardiomyopathy

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Clinical and genetic characteristics of α cardiac actin gene mutations in hypertrophic cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Clinical and genetic characteristics of α cardiac actin gene mutations in hypertrophic cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider