April 17, 2018Frontiers in PhysiologyOpen Access

Classifying Cardiac Actin Mutations Associated With Hypertrophic Cardiomyopathy

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Population

Patients with hypertrophic cardiomyopathy (HCM) associated with cardiac actin gene (ACTC1) mutations

Design

Review

Authors

EDEvan A. DespondUniversity of Guelph JDJohn DawsonUniversity of Guelph

Discussion

Member takes

Implication

ACTC1 mutation classification by location remains hypothesis-generating; prospective validation needed before clinical use.

Structured PICO

Population

Patients with hypertrophic cardiomyopathy (HCM) associated with cardiac actin gene (ACTC1) mutations

Intervention

Classification of ACTC1 mutations into M-class, T-class, and MT-class based on the location of the resulting amino acid change

A proposed structural classification of cardiac actin mutations may help integrate structural information with pathogenesis to develop targeted treatments for hypertrophic cardiomyopathy.

Cite This Study

Despond et al. (2018) studied this question.

synapsesocial.com/papers/6a91b85211b17c63ab5ce1ca https://doi.org/10.3389/fphys.2018.00405

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Classifying Cardiac Actin Mutations Associated With Hypertrophic Cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Classifying Cardiac Actin Mutations Associated With Hypertrophic Cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider