Calcium exchange in vascular smooth muscle, action of noradrenaline and lanthanum.

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Population

Rat aortae

Comparison

Incubation in physiological solution or solution… vs Controls in physiological solution

Design

Preclinical

Authors

Discussion

Hypothesis-generating for alpha-adrenergic vascular calcium handling; leaves open translation to human disease and therapy.

Population

Rat aortae

Intervention

Incubation in physiological solution or solution containing LaCl3 instead of CaCl2; exposure to noradrenaline and phentolamine

Comparator

Controls in physiological solution

Outcome

Na, K, Ca, and Mg content, and 45Ca uptake and losssurrogate

Noradrenaline increases calcium uptake in vascular smooth muscle via alpha-adrenergic receptor activation.

Théophile Godfraind (1976) studied this question.

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