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April 1, 1977The Journal of General PhysiologyOpen Access

A study of releasable Ca fractions in smooth muscle cells of the rabbit aorta.

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Population

Smooth muscle cells of the rabbit aorta

Comparison

Exposure to norepinephrine, caffeine, and DNP vs Various loading conditions including normal…

Design

Preclinical

Authors

RDRichard C. DethNova Southeastern UniversityRCR. CasteelsAmerican Heart Association

Discussion

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Implication

Highlights compartmentalized Ca²⁺ release in vascular smooth muscle; extends mechanistic understanding but leaves clinical translation open.

Structured PICO

P
Population
Smooth muscle cells of the rabbit aorta
I
Intervention
Exposure to norepinephrine, caffeine, and DNP
C
Comparator
Various loading conditions including normal solution, K-rich solution, and reduced [Ca]o solution
O
Outcome
45Ca exchange (efflux/release) and pattern of tension developmentsurrogate

Demonstrates distinct intracellular calcium pools in rabbit aortic smooth muscle cells, with norepinephrine and caffeine mobilizing calcium from a membrane-associated pool and DNP acting on mitochondria.

Cite This Study

Deth et al. (1977) studied this question.

synapsesocial.com/papers/6a82c6fe979d337bd44413dahttps://doi.org/10.1085/jgp.69.4.401
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Excitation-Contraction Coupling in Rabbit Aorta Studied by the Lanthanum Method for Measuring Cellular Calcium Influx1972 · 458 citations
  2. 2Inhibitory Effects of Caffeine on Developed Tension and Calcium Movement in Guinea Pig Taenia Coli in High-K Medium1975 · 9 citations
  3. 3THE EFFECT OF CAFFEINE AND RAPID COOLING ON SMOOTH MUSCLE1972 · 16 citations