Cardiac arrest in a young woman with the long QT syndrome and concomitant astemizole ingestion.

P. Broadhurst; A. W. Nathan

doi:10.1136/hrt.70.5.469

November 1, 1993HeartOpen Access

Cardiac arrest in a young woman with the long QT syndrome and concomitant astemizole ingestion.

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Structured PICO

P

Population

19-year-old woman with congenital long QT syndrome

I

Intervention

Astemizole

O

Outcome

Ventricular fibrillationsafety

Astemizole ingestion can aggravate congenital long QT syndrome and lead to life-threatening ventricular fibrillation.

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Implication

Astemizole may trigger VF in congenital LQTS; single case leaves open systematic risk assessment.

Abstract

Ventricular fibrillation developed in a 19 year old woman taking the antihistamine astemizole. She was successfully resuscitated. QTc prolongation was found and persisted despite withdrawal of the drug. Aggravation of congenital long QTc syndrome by astemizole is postulated. More caution should be exercised with the use of this drug.

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Cite This Study

Broadhurst et al. (1993) studied this question.

synapsesocial.com/papers/6a89c33e6099c687143344b4 https://doi.org/10.1136/hrt.70.5.469

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Cardiac arrest in a young woman with the long QT syndrome and concomitant astemizole ingestion.

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Cardiac arrest in a young woman with the long QT syndrome and concomitant astemizole ingestion.

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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