Exercise Training Improves Age-Related Myocardial Metabolic Derangement: Proton Magnetic Resonance Spectroscopy Study in the Rat Model
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Why the study?
Does long-term exercise training prevent age-related myocardial metabolic derangement in old rats?
Population
Young and old male Fischer 344 rats.
Comparison
12-week treadmill exercise training… vs Sedentary cage life.
Design
Preclinical, Old rats were randomly assigned into sedentary control, or…
Follow-up
12 weeks
Authors
Discussion
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Implication
Preclinical rat data suggest exercise preserves myocardial metabolism with aging; leaves open translation to human prevention strategies.
Structured PICO
Does long-term exercise training prevent age-related myocardial metabolic derangement in old rats?
P
Population
Young (3 months of age) and old (22 months of age) male Fischer 344 rats (n=25; young control n=10, old control n=10, old exercise-trained n=5).
I
Intervention
12-week treadmill exercise training, progressively increased to a terminal rate of 15 m/min for 45-60 minutes/day, 5 days per week.
C
Comparator
Sedentary cage life (walked or ran on the treadmill for 10 minutes per week to maintain familiarity).
O
Outcome
Myocardial energy metabolism assessed by creatine-to-water ratio (Scr/Sw) and mean total creatine concentration using 1H-MR spectroscopy at 4.7 T.surrogate
Long-term exercise training in an aged rat model prevents age-related deterioration in myocardial creatine metabolism as measured by proton MR spectroscopy.
Limitations
- Did not perform 31P-MR spectroscopy
- Measurements were made under light sedation
Cite This Study
Choi et al. (2010) studied this question.
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