August 9, 2007Journal of VirologyOpen Access

Identification and Characterization of Interferon-Induced Proteins That Inhibit Alphavirus Replication

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Population

Preclinical models: neonatal CD1 mice and murine fibroblast cultures (Tet-Off MEF cells)

Comparison

Overexpression or siRNA-mediated knockdown of… vs Control vectors or non-targeting siRNA

Design

Preclinical

Authors

YZYugen ZhangUniversity of North Carolina at Chapel Hill CBCrystal W. BurkeUnited States Army Medical Research Institute of Infectious Diseases KRKate D. RymanUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Supports ISG-focused alphavirus research; hypothesis-generating in preclinical models with no immediate clinical implications.

Structured PICO

Population

Preclinical models: neonatal CD1 mice and murine fibroblast cultures (Tet-Off MEF cells)

Intervention

Overexpression or siRNA-mediated knockdown of interferon-stimulated genes (ISG20, ISG15, ZAP, viperin, p56, p54, p49)

Comparator

Control vectors (eGFP, fLuc, MVH) or non-targeting siRNA

Outcome

Antiviral activity (virulence attenuation in mice and inhibition of Sindbis virus replication in vitro)surrogate

Specific interferon-stimulated genes, notably ZAP, ISG20, and viperin, demonstrate significant but context-dependent antiviral activity against alphaviruses.

Cite This Study

Zhang et al. (2007) studied this question.

synapsesocial.com/papers/6a89c93f176d2ac34cfbb7d2 https://doi.org/10.1128/jvi.01282-07

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Identification and Characterization of Interferon-Induced Proteins That Inhibit Alphavirus Replication

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification and Characterization of Interferon-Induced Proteins That Inhibit Alphavirus Replication

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider