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December 15, 1995Circulation

Lysophosphatidylcholine Inhibits Endothelium-Dependent Hyperpolarization andNω-Nitro- l -Arginine/IndomethacinResistant Endothelium-Dependent Relaxation in the Porcine Coronary Artery

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Population

Porcine coronary artery model

Comparison

Lysophosphatidylcholine at concentrations of 0… vs Control (absence of LPC)

Design

Preclinical

Authors

HEHiroshi EizawaKobe City Nishi-Kobe Medical CenterYYYoshiki YuiKyoto UniversityKKKunihiko KosugaCleveland Clinic

Discussion

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Implication

May impair coronary endothelial function in atherosclerosis; hypothesis-generating for LPC as a therapeutic target in humans.

Structured PICO

P
Population
Porcine coronary artery model
I
Intervention
Lysophosphatidylcholine (LPC) at concentrations of 0 to 20 mumol/L
C
Comparator
Control (absence of LPC)
O
Outcome
Endothelium-dependent relaxation (EDR) and membrane hyperpolarization induced by bradykinin or A23187 in the presence of N omega-nitro-L-arginine (NNA) and indomethacin (IM)surrogate

Lysophosphatidylcholine inhibits endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation and hyperpolarization in porcine coronary arteries, suggesting a novel regulatory mechanism in atherosclerosis.

Cite This Study

Eizawa et al. (1995) studied this question.

synapsesocial.com/papers/6a89c9491fb56efa37d46f2bhttps://doi.org/10.1161/01.cir.92.12.3520
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of amphiphiles on erythrocytes, coronary arteries, and perfused hearts1981 · 44 citations
  2. 2Lipoproteins are inhibitors of endothelium-dependent relaxation of rabbit aorta1990 · 46 citations
  3. 3Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein.1985 · 382 citations
  4. 4Bradykinin-Induced, Nω-Nitro-L-Arginine-Insensitive Endothelium-Dependent Relaxation of Porcine Coronary Arteries Is Not Mediated by Bioassayable Relaxing Substances1992 · 30 citations
  5. 5Muscarinic-activated K+ current in bovine aortic endothelial cells.1988 · 108 citations