Observations on the Use of Antithyroid Drugs

Article1 June 1964Observations on the Use of Antithyroid DrugsW. S. REVENO, M.D., F.A.C.P., H. ROSENBAUM, M.D., F.A.C.P.W. S. REVENO, M.D., F.A.C.P.Search for more papers by this author, H. ROSENBAUM, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-6-982 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn this report we have summarized twenty years' experience in the treatment of hyperthyroidism with antithyroid drugs. While the primary aim was to determine the long-term effectiveness of this form of therapy, the study provided the opportunity to observe the response in postoperative or recurrent hyperthyroidism, when pregnancy or diabetes complicated the thyrotoxicosis, and in iatrogenic disease. Also described are the unfavorable reactions to the drugs and several instances of unresponsiveness to treatment because of false hyperthyroidism.Thiouracil, the first drug used, has been replaced by propylthiouracil and methimazole, both drugs of high efficacy and low toxicity. Potassium perchlorate, the...References1. REVENO WS: Treatment of postoperative hyperthyroidism with antithyroid drugs. J. Clin. Endocr. 9: 1054, 1949. CrossrefGoogle Scholar2. REVENO WS: Observations on the use of thiouracil. Ann. Intern. Med. 25: 822, 1946. LinkGoogle Scholar3. ROSENBAUMREVENO HWS: Agranulocytosis and toxic hepatitis from methimazole. JAMA 152: 27, 1953. CrossrefMedlineGoogle Scholar4. HERSHMANGIVENSCASSIDYASTWOOD JHJRCEEB: Long-term outcome of hyperthyroidism treated with antithyroid drugs, reported at the 1963 meeting of the American Thyroid Association. Google Scholar5. SOLOMONBECKVANDERLAANASTWOOD DHJCWPEB: Prognosis of hyperthyroidism treated with antithyroid drugs. JAMA 152: 201, 1953. CrossrefMedlineGoogle Scholar6. ASPER SP: The treatment of hyperthyroidism. Arch. Intern. Med. (Chicago) 106: 878, 1960. CrossrefMedlineGoogle Scholar7. CHAPMAN EM: The treatment of hyperthyroidism. New Eng. J. Med. 265: 744, 844, 948, 1961. CrossrefMedlineGoogle Scholar8. REVENOROSENBAUM WSH: Chronic treatment of toxic diffuse goiter. Arch. Intern. Med. (Chicago) 100: 642, 1947. CrossrefGoogle Scholar9. HOWEFRANCIS PHH: Pregnancy and thyrotoxicosis. Brit. Med. J. 2: 817, 1962. CrossrefMedlineGoogle Scholar10. HERBSTSELENKOW ALHA: Hyperthyroidism in pregnancy. Obstet. Gynec. 21: 543, 1963. Google Scholar11. ASTWOOD EB: Management of thyroid disorders. JAMA 186: 585, 1963. CrossrefMedlineGoogle Scholar12. REVENO WS: Thiouracil effect in diabetes mellitus. Amer. J. Med. Sci. 211: 174, 1946. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: W. S. REVENO, M.D., F.A.C.P.; H. ROSENBAUM, M.D., F.A.C.P.Affiliations: Detroit, MichiganFrom the Department of Medicine, Harper Hospital, Detroit, Michigan.Requests for reprints should be addressed to William S. Reveno, M.D., 968 Fisher Building, Detroit, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPropylthiouracilRecurrence of hyperthyroidism in multinodular goiter after long-term drug therapy: A comparison with Graves’ diseasePLACE OF RADIOACTIVE IODINE IN TREATMENT OF THYROTOXICOSISRelapses after Thionamide Therapy for Graves' DiseaseIs There a Place for Long-Term Stable Iodine in the Treatment of Graves’ Disease?Thionamide Therapy in Graves' Disease: Relation of Relapse Rate to Duration of TherapyHAJIME TAMAI, M.D., TETSUYA NAKAGAWA, M.D., OSAMU FUKINO, M.D., NORIYUKI OHSAKO, M.D., RISHUN SHINZATO, M.D., HIROYUKI SUEMATSU, M.D., KANJI KUMA, M.D., FUMIO MATSUZUKA, M.D., SHIGENOBU NAGATAKI, M.D.Medical Treatment of HyperthyroidismAntithyroid drugsBenefits and risks in nuclear medicine.TREATMENT OF THYROTOXICOSIS WITH IONISING RADIATIONHyperthyroidismDAVID H. SOLOMON, M.D., F.A.C.P., L. ROBERT BENNETT, M.D., JOSIAH BROWN, M.D., J. B. PETER, M.D., PH.D., WILLIAM F. POLLOCK, M.D., JOHN B. RICHARDS, M.D.METHOTREXATE IN MENINGEAL LEUKÆMIATREATMENT OF THYROTOXICOSISHYPEROSMOLAR NON-KETOTIC COMAIdiopathic heart diseaseThe Treatment of HyperthyroidismJEROME M. HERSHMAN, M.D.Hyperthyroidism during Pregnancy 1 June 1964Volume 60, Issue 6Page: 982-989KeywordsAdverse reactionsAlcoholsBirthDrugsHospital medicineHyperthyroidismPotassiumPregnancyThyroidToxicity ePublished: 1 December 2008 Issue Published: 1 June 1964 PDF downloadLoading ...