Why the study?
Recent advances in cardiovascular magnetic resonance perfusion mapping enable rapid microvascular assessment, prompting investigation into whether microvascular dysfunction in Fabry disease associates with storage, fibrosis, and edema.
Does multiparametric cardiovascular magnetic resonance identify microvascular dysfunction in patients with Fabry disease compared to healthy controls?
Population
44 FD patients and 27 healthy controls
Comparison
FD patients vs healthy controls, and LVH+ vs LVH- FD
Design
Prospective observational study
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Supports early microvascular dysfunction detection by CMR in Fabry disease; leaves open its role as a pre-LVH marker pending prospective trials.
Does multiparametric cardiovascular magnetic resonance identify microvascular dysfunction in patients with Fabry disease compared to healthy controls?
Cardiovascular magnetic resonance perfusion mapping demonstrates that microvascular dysfunction is present in Fabry disease even before the development of left ventricular hypertrophy, serving as an early disease marker.
A 2019 study studied this question.
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