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January 22, 2015Thrombosis and Haemostasis

Predictors of thromboprophylaxis in hospitalised medical patients

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Why the study?

What clinical factors are associated with the use or absence of thromboprophylaxis in acutely ill medical patients?

Population

1,478 hospitalised acutely ill medical patients from eight large Swiss hospitals, stratified into high risk…

Comparison

Pharmacological or mechanical thromboprophylaxis vs No thromboprophylaxis

Design

Cohort

Authors

DSDavid SpirkUniversity of BernMNMathieu NendazUniversity of GenevaDADrahomir AujeskyVascular Medicine

Discussion

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Overview

Bleeding risks commonly prompt prophylaxis omission in high-risk patients; hypothesis-generating for refined decision tools and prospective trials.

Structured PICO

What clinical factors are associated with the use or absence of thromboprophylaxis in acutely ill medical patients?

P
Population
1,478 hospitalised acutely ill medical patients from eight large Swiss hospitals, stratified into high risk (Geneva Risk Score ≥ 3 points, n=962) and low risk (Geneva Risk Score < 3 points, n=516) of venous thromboembolism.
I
Intervention
Pharmacological or mechanical thromboprophylaxis
C
Comparator
No thromboprophylaxis
O
Outcome
Use of pharmacological or mechanical thromboprophylaxis

In acutely ill medical patients, bleeding and thrombocytopenia are the primary drivers for withholding thromboprophylaxis in high-risk patients, whereas its use in low-risk patients remains inconsistent.

Cite This Study

Spirk et al. (2015) studied this question.

synapsesocial.com/papers/6a89cd24186271ac9933503ahttps://doi.org/10.1160/th14-06-0525
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Also Consider

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  1. 1Multicentre validation of the Geneva Risk Score for hospitalised medical patients at risk of venous thromboembolism2013 · 115 citations
  2. 2Lack of prophylaxis before the onset of acute venous thromboembolism among hospitalized cancer patients: the SWIss Venous ThromboEmbolism Registry (SWIVTER)2009 · 49 citations
  3. 3Assessment of venous thromboembolism risk and the benefits of thromboprophylaxis in medical patients2005 · 249 citations
  4. 4Intermittent pneumatic compression and deep vein thrombosis prevention2005 · 194 citations