Efficacy and tolerability of azilsartan combined with amlodipine and amlodipine monotherapy and combinations of amlodipine with other angiotensin II receptor blockers

Objective. To evaluate the efficacy and safety of combining various angiotensin II receptor blockers with amlodipine compared with amlodipine alone, as well as intake of azilsartan 20—80 mg daily and amlodipine 5—10 mg daily compared to other angiotensin II receptor blockers combined with amlodipine in patients with hypertension. Material and methods. The review enrolled 22 clinical trials (21 RCTs and 1 observational study) and 9.708 patients. Among 21 RCTs, 19 studies were blinded and 2 RCTs were open-label. Results. We found more significant SBP decrease in case of combination of azilsartan with amlodipine compared to amlodipine alone (5 or 10 mg daily). Such advantages of combined antihypertensive therapy with azilsartan and amlodipine were more pronounced compared to combination of other ARBs with amlodipine. Moreover, these advantages of azilsartan combined with amlodipine were significantly clearer compared to valsartan or losartan. Conclusion. We found higher antihypertensive efficacy of azilsartan combined with amlodipine in comparison with combination of other ARBs and amlodipine monotherapy. Despite higher antihypertensive efficacy of azilsartan combined with amlodipine, safety of this therapy did not differ from combination of other ARBs with amlodipine or amlodipine monotherapy.