What question did this study set out to answer?

To evaluate the feasibility and therapeutic efficacy of reinfusing unpurified autologous bone marrow following high-dose conditioning in patients with acute myeloid leukemia in complete remission.

December 15, 1984CancerOpen Access

Transplantation of non-purified autologous bone marrow in patients with AML in first remission

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To evaluate the feasibility and therapeutic efficacy of reinfusing unpurified autologous bone marrow following high-dose conditioning in patients with acute myeloid leukemia in complete remission.
Administered high-dose cyclophosphamide and total body irradiation conditioning to patients with acute myeloid leukemia in complete remission (N=4).
Reinfused unpurified autologous bone marrow collected during remission, with no subsequent maintenance chemotherapy.
Prompt hematologic regeneration occurred in all 4 patients despite prior bone marrow exposure to high-dose induction chemotherapy.
Patients achieved durable remissions lasting 64+, 21, 40+, and 19+ months, with one death at 21 months resulting from medullary relapse.

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Implication

Interventional study reveals durable remissions in acute myeloid leukemia patients after unpurified autologous bone marrow grafting, suggesting marrow purging may be unnecessary.

Cite This Study

Löwenberg et al. (1984) studied this question.

synapsesocial.com/papers/6a89cd9d439f8b7e014339d6 https://doi.org/10.1002/1097-0142(19841215)54:12<2840::aid-cncr2820541204>3.0.co;2-4

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Implication

Interventional study reveals durable remissions in acute myeloid leukemia patients after unpurified autologous bone marrow grafting, suggesting marrow purging may be unnecessary.

Transplantation of non-purified autologous bone marrow in patients with AML in first remission

Key Points

Discussion

Implication

Cite This Study

Transplantation of non-purified autologous bone marrow in patients with AML in first remission

Key Points

Discussion

Implication

Cite This Study

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