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April 15, 1990Blood

Autologous bone marrow transplantation for acute myelocytic leukemia in first remission: a European survey of the role of marrow purging

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Authors

NGNC GorinUniversité Claude Bernard Lyon 1PAPhilippe AegerterInsermBAB AuvertInserm

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Overview

Multicenter cohort study reveals marrow purging reduces leukemia relapse after autologous transplantation in first remission, indicating clinical benefit for early autografts.

Key Points

  • Assess the effect of in vitro bone marrow purging with mafosfamide on relapse and leukemia-free survival in patients with acute myelocytic leukemia autografted during first remission.
  • Analyzed registry data from N=263 patients with acute myelocytic leukemia autografted in first remission across 34 European centers between 1982 and 1987, with a median follow-up of 28 months.
  • Compared outcomes between recipients of autologous marrow purged in vitro with mafosfamide (n=69) and unpurged marrow (n=194) following conditioning with total body irradiation (n=131) or chemotherapy regimens.
  • Among standard-risk patients conditioned with total body irradiation (n=107), marrow purging improved leukemia-free survival (63% vs 34%, P = .05) and reduced relapse probability (23% vs 55%; relative risk 0.34, P = .005).
  • Purging demonstrated maximum benefit in patients autografted within 6 months of remission, reducing relapse risk from 61% to 20% (P = .01).
  • Longer intervals between remission and autografting independently associated with better outcomes (intervals >9 vs ≤3 months: leukemia-free survival 56% vs 27%, P = .007; relapse probability 25% vs 67%, P = .005).

Cite This Study

Gorin et al. (1990) studied this question.

synapsesocial.com/papers/6a6ffdacce524a4339c3cbfdhttps://doi.org/10.1182/blood.v75.8.1606.1606
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