Pulmonary Hypertension and Refractory Heart Failure in a Patient with Crow-Fukase (POEMS) Syndrome

67-year-old man (n=1) with refractory heart failure, pulmonary hypertension, left ventricular diastolic dysfunction, severe sleep-disordered breathing, and Crow-Fukase (POEMS) syndrome.

Treatment for POEMS syndrome (melphalan, prednisolone, dexamethasone, thalidomide) and sleep-disordered breathing (continuous positive airway pressure and adaptive servo ventilation), along with diuretics.

Improvement in pulmonary arterial pressure, plasma VEGF levels, and sleep-disordered breathing parameters at 4 months follow-up.surrogate