Avascular Necrosis of the Femoral Head Associated with Sickle Cell Trait (AS Hemoglobin)

Case Studies1 August 1962Avascular Necrosis of the Femoral Head Associated with Sickle Cell Trait (AS Hemoglobin)RALPH G. RATCLIFF, M.D., MELVYN D. WOLF, M.D.RALPH G. RATCLIFF, M.D.Search for more papers by this author, MELVYN D. WOLF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-2-299 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis communication reports the occurrence of avascular necrosis of the femoral head in 2 patients with sickle cell trait (AS hemoglobin). Although this is known to occur in both sickle cell anemia (SS hemoglobin) (1) and in some of its genetic variants (2), we are unaware of any reports of avascular necrosis of the femoral head in association with pure sickle cell trait.METHODSStandard hematologic techniques were utilized for complete blood counts (3). Sickle cell tests were performed using 2% sodium metabisulfite (3).Fetal hemoglobin content was determined by the method of Singer, Chernoff, and Singer (4).Hemoglobin electrophoresis...References1. TANAKACLIFFORDAXELROD KRGOAR: Sickle cell anemia (homozygous S) with aseptic necrosis of femoral head. Blood 11: 998, 1956. CrossrefMedlineGoogle Scholar2. SMITHCONLEY EWCL: Clinical features of the genetic variants of sickle cell disease. Bull. Johns Hopkins Hosp. 94: 289, 1954. MedlineGoogle Scholar3. CARTWRIGHT GE: Diagnostic Laboratory Hematology, 2d Ed., Grune & Stratton, New York, 1958. Google Scholar4. SINGERCHERNOFFSINGER KAIL: Studies in abnormal hemoglobins. I. Their demonstration in sickle cell anemia and other hematologic disorders by means of alkali denaturation. Blood 6: 413, 1951. CrossrefMedlineGoogle Scholar5. Spinco Technical Bulletin 6095A, November, 1961, p. 14. Google Scholar6. NEELITANOLAWRENCE JVHAJS: Two cases of sickle cell disease presumably due to the combination of the genes for thalassemia and sickle cell hemoglobin. Blood 8: 438, 1953. CrossrefGoogle Scholar7. MYERSONHARRISONLOHMULLER RMEHW: Incidence and significance of abnormal hemoglobins. Amer. J. Med. 26: 543, 1959. CrossrefMedlineGoogle Scholar8. SMITHKREVANS EWJR: Clinical manifestations of hemoglobin C disorders. Bull. Johns Hopkins Hosp. 104: 17, 1959. MedlineGoogle Scholar9. SMITHCONLEY EWCL: Sicklemia and infarction of the spleen during aerial flight. Bull. Johns Hopkins Hosp. 96: 35, 1955. MedlineGoogle Scholar10. ROTTERLUTTGENSPETERSONSTOCKMOTULSKY RWFWLAEAG: Splenic infarction in sicklemia during airplane flight: pathogenesis, hemoglobin analysis and clinical features of six cases. Ann. Intern. Med. 44: 257, 1956. LinkGoogle Scholar11. KEITELTHOMPSONITANO HGDHA: Hyposthenuria in sickle cell anemia. J. Clin. Invest. 35: 998, 1956. CrossrefMedlineGoogle Scholar12. CRONEJEFFERSONPILEGGILOWRY RISCVJEC: Gross hematuria in sickle-cell trait. Arch. Intern. Med. 100: 597, 1957. CrossrefGoogle Scholar13. CHAPMANREEDERFRIEDMAN AZPSIA: Gross hematuria in sickle cell trait and sickle cell hemoglobin-C disease. Amer. J. Med. 19: 773, 1955. CrossrefMedlineGoogle Scholar14. CHERNOFF AI: Medical progress. The human hemoglobins in health and disease. New Engl. J. Med. 253: 365, 1955. CrossrefMedlineGoogle Scholar15. ENDEPIZZOLATOZISKIND OPJ: Sicklemia. Ann. Intern. Med. 42: 1065, 1955. LinkGoogle Scholar16. BAUERFISHER JLV: Sickle cell disease with special regard to its nonanemic variety. Arch. Surg. 47: 553, 1943. CrossrefGoogle Scholar17. GREENCONLEY TWCL: Occurrence of symptoms of sickle cell disease in the absence of persistent anemia. Ann. Intern. Med. 34: 849, 1951. LinkGoogle Scholar18. TSENG HL: Fatal cases of acute sicklemia. Arch. Path. 67: 339, 1960. Google Scholar19. MOTULSKY A: Sicklemia. J. A. M. A. 155: 388, 1954. CrossrefGoogle Scholar20. OBERBRUNOWEINBERGJONESWEINER WBMSJBFML: Fatal intravascular sickling in a patient with sickle-cell trait. New Engl. J. Med. 263: 947, 1960. CrossrefMedlineGoogle Scholar21. MCCORMICK WF: Pathology of sickle cell trait. Presented at fifty-seventh annual meeting of American Association of Pathologists and Bacteriologists, Memphis, Tennessee, April 28-30, 1960. Cited by Ober (20). Google Scholar22. WINTROBE MM: Clinical Hematology, 5th Ed., Lea & Febiger, Philadelphia, 1961, p. 688. Google Scholar23. WINTROBE MM: Clinical Hematology, 5th Ed., Lea & Febiger, Philadelphia, 1961, p. 675. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cincinnati, OhioFrom the Departments of Medicine and Surgery, University of Cincinnati College of Medicine; the Medical Service, Hematology Section, and the Surgical Service, Orthopedic Section, Cincinnati Veterans Administration Hospital, Cincinnati. Ohio.Requests for reprints should be addressed to Ralph G. Ratcliff, M.D., Veterans Administration Hospital, 3200 Vine Street, Cincinnati 20, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTotal hip arthroplasty: Concerns and precautions in sickle-cell traitMultiple Diaphyseal Bone Infarcts in a Patient With Sickle Cell TraitHistopathology of aseptic necrosis of the femoral head in sickle cell diseaseSickle-cell hip necrosis and intraosseous pressureOstéonécrose drépanocytaire de la tête fémorale et pression intraosseuseRetinopathy in haemoglobin C traitMalignant fibrous histiocytoma in bone infarct. Association with sickle cell trait and alcohol abuseThe early diagnosis of ischemic necrosis of boneHYPERLIPIDEMIA AND IDIOPATHIC ASEPTIC NECROSIS OF THE FEMORAL HEAD IN ADULTSThe morbidity of sickle cell traitRheumatological Manifestations of Sickle Cell Disease and other Hereditary HaemoglobinopathiesAvascular Necrosis and Erythrocytosis in Sickle-Cell TraitAseptic necrosis of the femoral head in a white boy with S-D hemoglobinopathyHemarthrosis and sickle cell traitAseptic necrosis of the femoral heads in sickle-A hemoglobin diseaseSickle Cell Trait and Superior Longitudinal Sinus ThrombosisERIC A. SCHENK, M.D.Roentgenologic Demonstration of Renal Papillary Necrosis in Sickle-Cell Trait 1 August 1962Volume 57, Issue 2_Part_1Page: 299-304KeywordsAnemiaGeneticsHematology and oncologyHemoglobinHospital medicineMedical servicesNecrosisOrthopedic surgeryOrthopedicsSodium Issue Published: 1 August 1962 PDF DownloadLoading ...