The Treatment of Acute Thrombotic Thrombocytopenic Purpura with Corticosteroids and Splenectomy

Article1 August 1966The Treatment of Acute Thrombotic Thrombocytopenic Purpura with Corticosteroids and SplenectomyReport of Three CasesARIEL DISTENFELD, M.D., ELLIOTT OPPENHEIM, M.D., F.A.C.P.ARIEL DISTENFELD, M.D.Search for more papers by this author, ELLIOTT OPPENHEIM, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-2-245 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince Moschowitz (1) published the first description of thrombotic thrombocytopenic purpura in 1925, case reports of this entity have appeared with increasing frequency in the medical literature. Over 270 cases have been reported in the world literature (2). The disease is diagnosed postmortem more frequently than antemortem and is still considered by many to be nearly uniformly fatal with no effective treatment (3-5). However, a small number of patients have been reported who have survived after treatment with corticosteroids and splenectomy (6).The purpose of this report is to report three additional patients treated with massive hormonal therapy and splenectomy....References1. MOSCHOWITZ E: Acute febrile pleochromic anemia with hyaline thrombosis of terminal arterioles and capillaries: undescribed disease. Arch. Intern. Med. (Chicago) 36: 89, 1925. CrossrefGoogle Scholar2. AMOROSIULTMAN ELJE: Thrombotic thrombocytopenic purpura: report of sixteen cases (abstract). Ann. Intern. Med. 61: 806, 1964. LinkGoogle Scholar3. WINTROBE MM: Clinical Hematology, 5th ed. 1186 pages. Lea & Febiger, Philadelphia, 1961. Google Scholar4. ANTES EH: Thrombotic thrombocytopenic purpura: review of the literature with report of a case. Ann. Intern. Med. 48: 512, 1958. LinkGoogle Scholar5. WASSERMAN E: Thrombohemolytic thrombocytopenic purpura: case report and review of the literature. Amer. J. Med. 24: 648, 1958. CrossrefMedlineGoogle Scholar6. HILLLOEB JME: Massive hormonal therapy and splenectomy in acute thrombotic thrombocytopenic purpura: report of three cases with one eight year cure. JAMA 173: 778, 1960. CrossrefGoogle Scholar7. CAHALANEHORN SFRC: Thrombotic thrombocytopenic purpura of long duration. Amer. J. Med. 27: 333, 1959. CrossrefMedlineGoogle Scholar8. ALTSHULE MD: Rare type of acute thrombocytopenic purpura: widespread formation of platelet thrombi in capillaries. New Eng. J. Med. 227: 477, 1942. CrossrefGoogle Scholar9. SINGERBORNSTEINWILE KFPSA: Thrombotic thrombocytopenic purpura: haemorrhagic diathesis with generalized platelet thrombosis. Blood 2: 542, 1947. CrossrefMedlineGoogle Scholar10. BERNSTOCKHIRSON LC: Thrombotic thrombocytopenic purpura. Remission on treatment with heparin. Lancet 1: 28, 1960. CrossrefMedlineGoogle Scholar11. TALBOTTMOLERES FERRAIDIS JHR: Collagen Diseases: Including Systemic Lupus Erythematosus, Polyarteritis, Dermatomyositis, Systemic Schleroderma, Thrombotic Thrombocytopenic Purpura. Grune & Stratton, Inc. New York, 1956. Google Scholar12. SCHWARTZMANKLEMPERERGERBER GPIE: Phenomenon of local tissue reactivity to bacterial filtrates: the role of altered vascular response in certain human diseases. JAMA 107: 1946, 1936. CrossrefGoogle Scholar13. LEVINESHEARN SMA: Thrombotic thrombocytopenic purpura and systemic lupus erythematosus. Arch. Intern. Med. (Chicago) 113: 826, 1964. CrossrefMedlineGoogle Scholar14. SOLOMONTURNESBLOCKPOSNER WDSCC: Thrombotic thrombocytopenic purpura in pregnancy. JAMA 184: 587, 1963. CrossrefMedlineGoogle Scholar15. SHAPIRODOKTORCHURG HDDJ: Thrombotic thrombocytopenic purpura (Moschowitz's disease): report of a case with remission after splenectomy and steroid therapy. Ann. Intern. Med. 47: 583, 1957. Google Scholar16. SIEGELFRIEDMANKESSLERSCHWARTZ BMIASSO: Thrombotic thrombocytopenic purpura and lupus erythematosus. Ibid., p. 1022. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New YorkFrom the Department of Medicine, New York University School of Medicine, New York, N. Y., and the New York University Medical Services at University and Bellevue Hospitals, New York, N. Y.Requests for reprints should be addressed to Ariel Distenfeld, M.D., 535 Park Ave., New York, N. Y. 10021. 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HARRIS, M.D.Antiplatelet Treatment of Thrombotic Thrombocytopenic PurpuraEDWARD L. AMOROSI, M.D., SIMON KARPATKIN, M.D.Thrombotic thrombocytopenic purpura as a cause of pancreatitis 1 August 1966Volume 65, Issue 2Page: 245-251KeywordsHormonal therapyHospital medicineMedical servicesSplenectomyThrombotic thrombocytopenic purpura Issue Published: 1 August 1966 PDF downloadLoading ...