Population
Mice with cerebral ischemia
Comparison
Cerebral ischemia vs Wild-type mice
Design
Preclinical
Authors
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Questions NOS-2 knockout completeness in ischemia models; leaves open alternative promoter mechanisms for validation in higher models.
This study identifies a previously unknown promoter region for NOS-2 that is activated following cerebral ischemia in vivo, providing a new model to study NOS-2 gene regulation.
Loihl et al. (1999) studied this question.
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