Integrated respiratory chemoreflex‐mediated regulation of cerebral blood flow in hypoxia: Implications for oxygen delivery and acute mountain sickness
Why the study?
The extent to which hypoxia-induced changes in peripheral and central respiratory chemoreflexes modulate anterior versus posterior cerebral oxygen delivery and influence acute mountain sickness was unknown.
Does hypoxia exposure alter regional cerebral blood flow and oxygen delivery compared to normoxia in healthy men?
Population
Eight healthy men
Comparison
7 h passive exposure to normoxia (21% O2) vs hypoxia (12% O2)
Design
Single-blind randomized trial
Follow-up
7 h
Authors
Discussion
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Member takes
Implication
Hypoxia selectively impairs anterior cerebral oxygen delivery; extends RCT evidence for site-specific cerebrovascular regulation in AMS.
Structured PICO
Does hypoxia exposure alter regional cerebral blood flow and oxygen delivery compared to normoxia in healthy men?
P
Population
8 healthy men
I
Intervention
7 h of passive exposure to hypoxia (12% O2)
C
Comparator
7 h of passive exposure to normoxia (21% O2)
O
Outcome
Peripheral and central respiratory chemoreflex, internal carotid artery, external carotid artery (ECA) and vertebral artery blood flow, and acute mountain sickness (AMS) scoressurrogate
Hypoxia induces site-specific regulation of cerebral blood flow, preserving posterior but not anterior cerebral oxygen delivery, with external carotid artery vasodilatation potentially predisposing to acute mountain sickness.
Cite This Study
Ogoh et al. (2021) studied this question.