Key result
Acute ventilatory responses to hypoxia in high-altitude natives and chronic mountain sickness patients were approximately one-third of those observed in sea-level natives.
Why the study?
How does peripheral chemoreflex function differ between high-altitude natives, patients with chronic mountain sickness, and sea-level natives?
Observational
How does peripheral chemoreflex function differ between high-altitude natives, patients with chronic mountain sickness, and sea-level natives?
High-altitude natives and patients with chronic mountain sickness have significantly blunted acute ventilatory responses to hypoxia compared to sea-level natives.
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Warrants caution extrapolating sea-level norms to highlanders; leaves open chemoreflex role in chronic mountain sickness pathogenesis.
Lèon‐Velarde et al. (2003) conducted an observational in Chronic mountain sickness and high-altitude adaptation. High-altitude native status and chronic mountain sickness vs. Sea-level natives was evaluated on Acute ventilatory responses to hypoxia (AHVR). Acute ventilatory responses to hypoxia in high-altitude natives and chronic mountain sickness patients were approximately one-third of those observed in sea-level natives.
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