revealed antibody and therefore a state of inm unity. The seronegative cases have re- main.d seronegaFive after Ig prophylaxis and have delivered normal children with no increased levels of IgM in the cord sample. On the other hand if seroconversion had occurred following the administration of Ig the patient and her medical practitioner could be advised accordingly, but this has not occurred in our experience. It would probably be preferable, as suggested by Drs. Forrest and Menser, to have an Ig preparation with a high antibody titre, but as this is not generally available and becaus,e there is some variation in the antibody titre of the normal pooled Ig product, we have used a large dose of 3 g administered in two separate doses. Though this is considerably greater than what is advocated we think it is justifiable in the circumtances.-I am, etc.,
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Wainscott et al. (1974) studied this question.