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August 1, 1977Circulation ResearchOpen Access

Role of converting enzyme in the responses of rabbit atria, aortas, and adrenal zona glomerulosa to des-Asp1angiotensin I.

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Population

Rabbit aortic strips, left atria, adrenal zone glomerulosa cell suspensions, and purified rabbit lung…

Comparison

[des-Asp1]angiotensin I and Angiotensin I in the… vs Angiotensin II and Angiotensin III

Design

Preclinical

Authors

JAJohn A. AckerlyCleveland ClinicBTB S TsaiArie Crown Hebrew Day SchoolMPM J PeachLancaster University

Discussion

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Implication

Supports alternative angiotensin III pathway in vitro; leaves open physiological relevance in vivo.

Structured PICO

P
Population
Rabbit aortic strips, left atria, adrenal zone glomerulosa cell suspensions, and purified rabbit lung converting enzyme
I
Intervention
[des-Asp1]angiotensin I and Angiotensin I in the presence or absence of converting enzyme inhibitor (Bothrops jararaca nonapeptide)
C
Comparator
Angiotensin II and Angiotensin III
O
Outcome
Peptide-induced tension development in aortas and atria, and steroidogenesis in adrenal cell suspensionssurrogate

The study demonstrates that [des-Asp1]angiotensin I is rapidly converted by converting enzymes, supporting an alternative pathway for Angiotensin III formation.

Cite This Study

Ackerly et al. (1977) studied this question.

synapsesocial.com/papers/6a8a3e8a1c70e695d843562ahttps://doi.org/10.1161/01.res.41.2.231
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Des-Asp-1-Angiotensin II: Possible Role in Mediating the Renin-Angiotensin Response in the Rat1976 · 5 citations
  2. 2Angiotensin III: (DES-Aspartic Acid-1)-Angiotensin II. Evidence and speculation for its role as an important agonist in the renin - angiotensin system.1975 · 116 citations
  3. 3Angiotensin I: Metabolism by Plasma Membrane of Lung1972 · 97 citations
  4. 4Single Glomerular Blood Flow as Measured with Carbonized 141‐Ce Labelled Microspheres1972 · 30 citations
  5. 5THE EFFECT OF THE HEPTAPEPTIDE (2-8) AND HEXAPEPTIDE (3-8) FRAGMENTS OF ANGIOTENSIN II ON ALDOSTERONE SECRETION11971 · 174 citations