February 1, 1981Endocrinology

des-Asp-Angiotensin I: Its Identification in Rat Blood and Confirmation as a Substrate for Converting Enzyme

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Population

Conscious rats

Comparison

Infusion of des-Asp1-[Ile5]angiotensin I at 50… vs Dextrose infusion

Design

Preclinical

Authors

GRGARCIA C. DEL RIOWestern Infirmary SASTUART W. SMELLIE AWestern Infirmary JMJames J. MortonWestern Infirmary

Discussion

Member takes

Implication

Animal data should not guide therapy; leaves open alternative angiotensin III formation pathway for human study.

Structured PICO

Population

Conscious rats

Intervention

Infusion of des-Asp1-[Ile5]angiotensin I at 50, 150, and 450 ng/kg . min, with or without captopril

Comparator

Dextrose infusion

Outcome

Plasma concentration of angiotensin IIIsurrogate

This study demonstrates that des-Asp-angiotensin I is a substrate for converting enzyme in rats, suggesting an alternative pathway for the formation of angiotensin III.

Cite This Study

RIO et al. (1981) studied this question.

synapsesocial.com/papers/6a8a3e8a1c70e695d8435628 https://doi.org/10.1210/endo-108-2-406

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Bookmark

des-Asp-Angiotensin I: Its Identification in Rat Blood and Confirmation as a Substrate for Converting Enzyme

Discussion

Member takes

Implication

Structured PICO

Cite This Study

des-Asp-Angiotensin I: Its Identification in Rat Blood and Confirmation as a Substrate for Converting Enzyme

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider