Population
15 pentobarbital-anesthetized dogs
Comparison
Bolus injections of [des-Asp1]angiotensin I and… vs Responses compared between the two agonists, and…
Design
Preclinical
Authors
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Suggests local angiotensin conversion in mesenteric vessels; hypothesis-generating for splanchnic regulation, requiring human validation before clinical relevance.
The decrease in mesenteric blood flow produced by [des-Asp1]angiotensin I is largely caused by its local enzymatic conversion to angiotensin III in the mesenteric vasculature.
Sexton et al. (1979) studied this question.
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