January 1, 1980Circulation ResearchOpen Access

A comparison of angiotensin II and angiotensin III as vasoconstrictors in the mesenteric circulation of dogs.

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Why the study?

Does angiotensin II have a greater vasoconstrictor effect than angiotensin III in the mesenteric circulation of anesthetized dogs?

Population

31 dogs anesthetized with pentobarbital

Comparison

Angiotensin II vs Angiotensin III

Design

Preclinical

Authors

SBSteven L. BrittonGeneral / Preventive / Lipids JSJ. M. Sexton MFM. J. Fiksen-OlsenCross-Cutting Cardiology

Discussion

Member takes

Implication

Angiotensin II potency in canine mesentery warrants no clinical extrapolation; leaves open peptide-specific effects in human splanchnic regulation.

Structured PICO

Does angiotensin II have a greater vasoconstrictor effect than angiotensin III in the mesenteric circulation of anesthetized dogs?

Population

31 dogs anesthetized with pentobarbital

Intervention

Angiotensin II (bolus injections 10-160 pmol or constant infusions 30 pmol/min per kg intra-arterially; 40 pmol/min per kg intravenously)

Comparator

Angiotensin III (bolus injections 10-160 pmol or constant infusions 30 pmol/min per kg intra-arterially; 80 pmol/min per kg intravenously)

Outcome

Mesenteric blood flow (duration, graphic integration of response, and absolute change in amplitude)surrogate

Angiotensin II is a more potent mesenteric vasoconstrictor than angiotensin III, contributing to its greater effect on arterial pressure, independent of prostaglandins.

Cite This Study

Britton et al. (1980) studied this question.

synapsesocial.com/papers/6a840e9a22fbfbf8d78d68ca https://doi.org/10.1161/01.res.46.1.146

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Implication

Angiotensin II potency in canine mesentery warrants no clinical extrapolation; leaves open peptide-specific effects in human splanchnic regulation.

A comparison of angiotensin II and angiotensin III as vasoconstrictors in the mesenteric circulation of dogs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A comparison of angiotensin II and angiotensin III as vasoconstrictors in the mesenteric circulation of dogs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider